BioVal plus: informative sheet

BioVal leaflet (Italian version)

STRAIN DEPOSITED IN ACCORDANCE TO THE TREATY OF BUDAPEST and DIRECTIVE 70/524 CEE
(Sheet N. 24)

BioVal PLUS^®

DIETARY SUPPLEMENT- INTESTINAL BIOREGULATOR TO BOOST THE IMMUNE SYSTEM
with Probiotic Lactic Yeast^®  Kluyveromyces B0399 (Turval B0399^®)

MEDICAL CONSULTANTS :

Dott. Zilli Maurizio, Gastroenterologia ed Endoscopia Digestiva
Osp.S.M.della Misericordia-Udine;

Dr. S. Andreoli – Doctor in Medicine and Surgery; Specialist in Diseases of the Degistive Syste,  Endoscope specialist at the S.Camillo Hospital, Treviso; Gastroenterology consultant at the Città della Salute, (Ud) -  at the Salus Alpe Adria   Pagnacco (Ud) -  at the Clinica S. Eufemia Grado (Go);

Prof. Giorgio Mustacchi (Centro Oncologico Azienda per i Servizi sanitari N° 1 – triestina, Università degli Studi di Trieste)

SCIENTIFIC CONSULTANTS :

Prof. P. Brigidi Dipartimento di scienze farmaceutiche,Alma mater studiorum · Università di Bologna;

Dott. S.Maccaferri - Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

Prof. C.V. Bruschi – International Centre for Genetic Engineering and Biotechnology(ICGEB) - Trieste Itlay.

Prof. A. Tulli – Director of the Clinic of Dermatology, University of Studies “G. d’Annunzio” Chieti (Italy)

DIETARY SUPPLEMENT 

CHARACTERISTICS OF THE ACTIVE INGREDIENTS

The benefits of brewer's yeast and the innovative coupling with lactic yeast
Turval Laboratories have developed and patented a biotechnological production process for the selection of particular strains of highly efficient lactic yeasts, resolving at the same time problems of stability and of preservation which in the past were the main obstacles for the utilization of these probiotics.
The singular mechanism of action of BioVal, which takes place predominantly in the intestine, is characteristic of the strain of Kluyveromyces fragilis B0399, activated by an appropriate balanced mix containing fiber and hydrolyzed proteins, to which the vitaminic and proteinic contribution of Saccharomyces cerevisiae is added.
The Probiotic Lactic Yeast^®  Kluyveromyces B0399 (Turval B0399^®) contained in BioVal PLUS, though presenting similar biological characteristics to active natural yeasts (i.e. brewer's yeast), stand out for their higher proteinic content and for their marked enzymatic activity which is able to demolish carbohydrates (lactose in particular, thanks to the enzyme beta-galactosidase) into simple sugars with the formation of lactic acid. This acid, by lowering or even blocking the pH in some tracts of the intestine, favors the bioregulation and modulation of the intestinal bacterial flora (probiotic action) slowing the development of the proteolitic type of microbic flora (enteric coliforms) and promoting the development of the so-called "beneficial" intestinal flora (i.e. Lactobacilli) which allows for a correct digestion of food, the development of competitive action on pathogenic micro-organisms and consequently a better assimilation of the nutritional elements.
The particular property of the lactic yeasts contained in BioVal PLUS is its capacity to maintain a marked replication vitality even at very low pH levels (3 – 3.5) . In virtue of their high chitin content, they are therefore resistant to the action of gastric juices and can effectively reach the intestinal tract where they carry out their metabolic activity.

BENEFITS

BioVal plus , by bioregulating and modulating the intestinal bacterial flora, is able to prevent (prophylactic effect) and to ward off all intestinal problems caused by alterations of the bacterial flora (intestinal dismicrobism). The intestinal bacterial flora can undergo changes for different reasons: incorrect or unbalanced diet, an imperfect digestion, stress from physical or mental fatigue, antibiotic therapies, debilitations following pharmacological treatments, physical exhaustion and also from psychological and emotional factors which lead to an irritability of the colon.
BioVal plus is recommended as an adjuvant to treatment and as a preventive treatment in cases which manifest or could manifest intestinal dismicrobism.
Furthermore, the lactic yeasts present in BioVal plus , because of their particular enzymatic makeup, "demolish" cow's milk and its dairy by-products, thus carrying out a significantly favorable action for those individuals who are intolerant to lactose.

PROBIOTIC USE NEEDS TO STRENGTHEN THIS DEFENSE SYSTEM AND HELP THE HOST PROTECT ITSELF AGAINST PATHOGENS AND ALTERATIONS TO THE INTESTINAL MUCOSA

This occurs because of Probiotic Lactic Yeas®  Kluyveromyces B0399 (Turval B0399®):

IS A HIGH LACTIC FERMENTATION YEAST THAT:

- SURPASSES THE GASTRIC BARRIER thanks to the chitin constituent on the cell wall

(trial n.35 - 79 -130.1)

- ARRIVES IN THE INTESTINE ACTIVE AND ALIVE and is capable of colonizing, thanks to its highlighted vitality also at a pH 3 – 3.5
(trial n. 130.4 - 79 -130.1 - 143)

- HAS NATURALLY ANTIBIOTIC RESISTANCE because Kluyveromyces B0399 is a yeast, not a bacterium, and thanks to the high content of chitin in the cell wall, it is not damaged by common and most used antibiotics

(trial n. trial 84)

- it respects natural personal/individual gut flora becoming  A FRENDLY, NATURAL AND RESPECTFUL PROBIOTIC: Kluyveromyces B0399 put only few foreign cells in your gut flora thanks  low dosage (100 times less then S. boulardii and lactobacilli proucts )  , but also because it is naturally found in daily food (cheese and other derivatives ....) so it take part naturally of human gut flora.

(trial n. 132 - 130.1 - 138 - 143)

- It COLONIZES THE INTESTINE: it is extremely adhesive to human enterocytes of the intestinal epithelium;

(trial n. 143)

- It MODULATES THE IMMUNE RESPONSE through: a) fine modulation of the level of anti- and pro- inflammatory cytokines, possibly attenuating the proinflammatory effect in inflammatory disorders such as irritable bowel syndrome (IBS) and Celiac Disease, among others; b) as a rich  source of PREBIOTICS, it gives rise to immunostimulating beta-glucans and oligo saccharides (GOS, MOS, FOS).

(trial n. 96A B, 129)

- BREAKS LACTOSE, thanks to the elevated production of ß-galactosidase (enzyme responsible for the splitting of lactose), therefore Kluyveromyces B0399 is particularly recommended for those who are lactose intolerant.

(trial n. 35)

- HAS ANTIMICOTIC ACTION, particularly against “candida albicans”

(trial n. 96A - 129)

-IS CAPABLE OF PERFORMING BIOREGULATORY ACTION AND MODULATION OF THE BACTERIAL INTESTINAL FLORA through:

((trial n. 16 - 132 - expertise Bottona 2009)

-the enzymatic degradation of lactose

-production of the highest dose of lactic acid (with respect to other probiotics)

-lowering of the intestinal pH (contained within physiological limits)

-death or minor development of putrefactive pathogenic flora (clostridia, coliforms etc.)

-stimulating the increase of the concentration of Bifidobacteria

*Pag 24 of EFSA QPS 2013 update - EFSA Journal;

INGREDIENTS

Probiotic Lactic Yeas^®  Kluyveromyces B0399 (Turval B0399^®) , fiber, hydrolyzed proteins), active brewer's yeast (Saccaromyces cerevisiae).

PACKAGING

Dosage:
- pediatric: 1 cps/die or medical opinion (the contents of the capsule can be
mixed in liquids or foods, not boiling – T <37°C)
- adults: 1-2 cps/die or medical opinion (you should take 2 capsules for the first week and 1 capsule in the next - the 2 cps could be taken even once, before or after meals ;

Dosage:
- pediatric: 1 bottle/die or medical opinion (do not need storage in     refrigerator )
- adults: 1-2 bottle/die or medical opinion (you should take 2 bottles for the first week and 1 bottle in the next - the 2 bottles could be taken before or after meals  - do not need storage in refrigerator )

Dosage:

- adults: 1 sachet/die or medical opinion (it is recommended to take the product for a period not exceeding 20 consecutive days - Any resumption is     recommended after approximately 20 days after the first treatment)
- contraindicated in children  (< 12 years), pregnancy and the presence of kidney disease.

   official supplier of the Italian Army;