PENDING PATENT: Topical, oral pharmaceutical composition for use in the treatment of inflammatory diseases of the oral cavity

BACKGROUND:

The project Parobio and the described patent are the results of proven efficacy of the probiotic yeast Kluyveromvces marxianus fragilis B0399 in dental treatment in testing performed by Dr. Stefani RP on 18 patients who demonstrated a rapid and significant improvement of the typical clinical characteristics of inflammation. In detail:

– PAIN on probing: disappeared after 7 days of treatment

– SWELLIG: resolved after 14 days

– REDNESS: resolved after 14 days

– BLEEDING: disappeared after 14 days

INVENTOR:

Dr. Roberto Pietro Stefani

FIELD: Dentistry

INVENTION DESCRIPTION/STATE OF THE ART:

The present patent relates to the use of Kluyveromyces marxianus fragilis B0399 in the treatment of inflammatory diseases of the oral cavity such as, for example, gingivitis, periodontitis, peri-implant mucositis and peri-implantitis.

The active ingredient of the composition consists of at least one probiotic yeast capable of overcoming the gastric barrier unscathed (i.e. say, the gastric juices of the stomach, and bile) and to reach the intestine alive and active. More specifically, the active ingredient consists of at least one yeast belonging to the genus Kluyveromyces, in particular, at least the yeast Kluyveromyces marxianus fragilis B0399.

The diseases of the oral cavity of interest for the present invention are well-known inflammatory diseases such as, for example, gingivitis, periodontitis, peri-implant mucositis and peri-implantitis.

EFFECT: implementation of the invention allows to develop an effective agent with enhanced therapeutic efficacy and safety.